Deletion of osteopontin or bone sialoprotein induces opposite bone responses to mechanical stimulation in mice.

ABSTRACT: Osteopontin (OPN) and Bone Sialoprotein (BSP) are co-expressed in bone and display overlapping and complementary physiological properties. Both genes show a rapid expression response to mechanical stimulation. We used mice with single and double deletions (DKO) of BSP and OPN to assess the specificity of their roles in skeletal adaptation to loading. Two-month-old Wild-Type (WT), BSP knockout (BSP^-/-), OPN^-/- and DKO male mice were submitted to two mechanical stimulation regimen (n = 10 mice/group) respectively impacting trabecular bone (Hypergravity, HG) and cortical bone (Whole Body Vibration, WBV). HG increased trabecular bone volume (BV/TV) in WT femur through reduced resorption, and in BSP^-/- mice femur and vertebra through increased bone formation. In

SUBMITTER: Maalouf M 

PROVIDER: S-EPMC9493388 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature