Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis.

ABSTRACT:

Background

Serum neurofilament light (sNfL) chain is a promising biomarker reflecting neuro-axonal injury in multiple sclerosis (MS). However, the ability of sNfL to predict outcomes in real-world MS cohorts requires further validation.

Objective

The aim of the study is to investigate the associations of sNfL concentration, magnetic resonance imaging (MRI) and retinal optical coherence tomography (OCT) markers with disease worsening in a longitudinal European multicentre MS cohort.

Methods

MS patients (n = 309) were prospectively enrolled at four centres and re-examined after 2 years (n = 226). NfL concentration was measured by single molecule array assay in serum. The patients' phenotypes were thoroughly characterized with clinical examination, retinal

SUBMITTER: Brune S 

PROVIDER: S-EPMC9493412 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature