Vitamin D₃ deficiency induced intestinal inflammatory response of turbot through nuclear factor-κB/inflammasome pathway, accompanied by the mutually exclusive apoptosis and autophagy.

ABSTRACT: Vitamin D₃ (VD₃) participated widely in the nuclear factor-κB (NF-κB)-mediated inflammation, apoptosis, and autophagy through the vitamin D receptor (VDR). However, the molecular mechanisms remain not understood in teleost. The present study investigated the functions of VD₃/VDR on intestinal inflammation, autophagy, and apoptosis of turbot in vivo and in vitro. Triple replicates of 30 fish were fed with each of three diets with graded levels of 32.0 (D₀), 1012.6 (D₁), and 3978.2 (D₂) IU/kg VD₃. Obvious intestinal enteritis was observed in the D₀ group and followed with dysfunction of intestinal mucosal barriers. The intestinal inflammatory response induced by VD₃ deficiency was

SUBMITTER: Chen Z 

PROVIDER: S-EPMC9493454 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature