VISTA is associated with immune infiltration and predicts favorable prognosis in TNBC.

ABSTRACT:

Background

V-domain Ig-containing suppressor of T cell activation (VISTA), a critical immune checkpoint protein, can regulate the immune system. Nevertheless, little information is available on the expression level of VISTA and its clinical significance as well. The immunological and prognostic role of VISTA in triple-negative breast cancer (TNBC) still remains unclear.

Methods

The clinical significance and expression of VISTA in TNBC were examined using RNA sequencing and clinical data. Cancer single-cell state atlas (CancerSEA), gene set enrichment analyses (GSEA), single sample GSEA, ESTIMATE algorithm, immunohistochemistry (IHC) were utilized to assess the functions of VISTA.

Results

VISTA was down-regulated and closely associated with good prognosis in TNBC. The

SUBMITTER: Zhang M 

PROVIDER: S-EPMC9493462 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature