Cytochrome P450 1A1 is essential for the microbial metabolite, Urolithin A-mediated protection against colitis.

ABSTRACT:

Background

Cytochrome P450 Family 1 Subfamily A Member 1 (CYP1A1) pathway, which is regulated by aryl hydrocarbon receptor (AhR) plays an important role in chemical carcinogenesis and xenobiotic metabolism. Recently, we demonstrated that the microbial metabolite Urolithin A (UroA) mitigates colitis through its gut barrier protective and anti-inflammatory activities in an AhR-dependent manner. Here, we explored role of CYP1A1 in UroA-mediated gut barrier and immune functions in regulation of inflammatory bowel disease (IBD).

Methods

To determine the role of CYP1A1 in UroA-mediated protectives activities against colitis, we subjected C57BL/6 mice and Cyp1a1 ^-/- mice to dextran sodium sulphate (DSS)-induced acute colitis model. The phenotypes of the mice were

SUBMITTER: Ghosh S 

PROVIDER: S-EPMC9493474 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature