Brain structural alterations in young girls with Rett syndrome: A voxel-based morphometry and tract-based spatial statistics study.

ABSTRACT: Rett syndrome (RTT) is a neurodevelopmental disorder caused by loss-of-function variants in the MECP2 gene, currently with no cure. Neuroimaging is an important tool for obtaining non-invasive structural and functional information about the in vivo brain. Multiple approaches to magnetic resonance imaging (MRI) scans have been utilized effectively in RTT patients to understand the possible pathological basis. This study combined developmental evaluations with clinical severity, T1-weighted imaging, and diffusion tensor imaging, aiming to explore the structural alterations in cohorts of young girls with RTT, idiopathic autism spectrum disorder (ASD), or typical development. Voxel-based morphometry (VBM) was used to determine the voxel-wised volumetric characteristics of gray ma

SUBMITTER: Li D 

PROVIDER: S-EPMC9493495 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature