Association of serum globulin with all-cause mortality in incident hemodialysis patients.

ABSTRACT:

Background

Serum globulin is a major component of total protein and can be elevated in inflammatory disease states. While inflammation is common in hemodialysis patients and associated with mortality and morbidity, the association between serum globulin and mortality has never been examined in hemodialysis patients.

Methods

In a retrospective cohort of 104 164 incident hemodialysis patients treated by a large dialysis organization from 2007 to 2011, we explored the association between baseline serum globulin, albumin: globulin (A:G) ratio and serum protein levels and all-cause, cardiovascular and infection-related mortality with adjustments for demographic variables and laboratory markers of malnutrition and inflammation using Cox proportional hazards models.

Results

SUBMITTER: Pai AY 

PROVIDER: S-EPMC9494081 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature