Why are women with polycystic ovary syndrome obese?

ABSTRACT:

Introduction

Polycystic ovary syndrome (PCOS) is a common condition characterized by reproductive, hyperandrogenic and dysmetabolic features, and often becomes clinically manifest during adolescence, particularly with weight-gain.

Sources of data

Pubmed search.

Areas of agreement

PCOS is heritable and closely associates with obesity (based on data from both epidemiological and genetic studies). Furthermore, insulin resistance forms a central cornerstone of the pathogenesis of PCOS and mediates a close association between obesity and the severity of the phenotypic features of PCOS.

Areas of controversy

Our understanding of the pathogenesis of PCOS remains incomplete, especially regarding its missing heritability (with only a small fraction having been identified

SUBMITTER: Barber TM 

PROVIDER: S-EPMC9494255 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature