Association of Empagliflozin Treatment With Albuminuria Levels in Patients With Heart Failure: A Secondary Analysis of EMPEROR-Pooled.

ABSTRACT:

Importance

Albuminuria, routinely assessed as spot urine albumin-to-creatinine ratio (UACR), indicates structural damage of the glomerular filtration barrier and is associated with poor kidney and cardiovascular outcomes. Sodium-glucose cotransporter-2 (SGLT2) inhibitors have been found to reduce UACR in patients with type 2 diabetes, but its use in patients with heart failure (HF) is less well studied.

Objective

To analyze the association of empagliflozin with study outcomes across baseline levels of albuminuria and change in albuminuria in patients with HF across a wide range of ejection fraction levels.

Design, setting, and participants

This post hoc analysis included all patients with HF from the EMPEROR-Pooled analysis using combined individual patient data from

SUBMITTER: Ferreira JP 

PROVIDER: S-EPMC9494272 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature