The multifaceted role of neurofilament light chain protein in non-primary neurological diseases.

ABSTRACT: The advancing validation and exploitation of cerebrospinal fluid and blood neurofilament light chain protein as a biomarker of neuroaxonal damage has deeply changed the current diagnostic and prognostic approach to neurological diseases. Further, recent studies have provided evidence of potential new applications of this biomarker also in non-primary neurological diseases. In the present review we summarise the current evidence, future perspectives, but also limitations, of neurofilament light chain protein as a cerebrospinal fluid and blood biomarker in several medical fields, including intensive care, surgery, internal medicine and psychiatry. In particular, neurofilament light chain protein is associated with the degree of neurologic impairment and outcome in patients admitted to intens

SUBMITTER: Abu-Rumeileh S 

PROVIDER: S-EPMC9494370 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature