Dupilumab use is associated with protection from COVID-19 mortality: A retrospective analysis.

ABSTRACT: We previously found that type 2 immunity promotes COVID-19 pathogenesis in a mouse model. To test relevance to human disease we used electronic health record databases and determined that patients on dupilumab (anti-IL-4R monoclonal antibody that blocks IL-13 and IL-4 signaling) at the time of COVID-19 infection had lower mortality.

SUBMITTER: Donlan AN 

PROVIDER: S-EPMC9494491 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature