Proteomic and miRNA profiling of radon-induced skin damage in mice: FASN regulated by miRNAs.

ABSTRACT: Radon is a naturally occurring radioactive gas and considered as a serious carcinogen to humans. Continuous radioactive decay of this gas emits high-energy alpha particles. Long-term radon exposure induces oxidative stress and inflammatory response, which results in chronic lung diseases. However, biological effects after radon exposure in other organs have been rarely reported. As the outermost organ of the human body, the skin suffers from environmental damage to agents such as air pollution. Epidemiological studies indicated that areas with high level of radon had a high incidence of skin cancer. However, whether radon exposure induces skin damage has not been reported yet. In this study, we established a radon-exposed mouse model and found that radon exposure affected the structure of

SUBMITTER: Mo W 

PROVIDER: S-EPMC9494515 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature