Comparative efficacy of patiromer and sodium polystyrene sulfonate on potassium levels in chronic haemodialysis patients: a randomized crossover trial.

ABSTRACT:

Background

Hyperkalaemia is frequent in haemodialysis (HD) patients and associated with increased cardiovascular mortality. Despite routine clinical use, evidence regarding the efficacy of potassium (K⁺) binders in HD is scant. We wished to compare the efficacy of patiromer (PAT) and sodium polystyrene sulfonate (SPS) on K⁺ levels in this setting.

Methods

We screened patients in three HD centres with pre-HD K⁺ value between 5.0 and 6.4 mmol/L, after an initial 2-week washout period for those previously on K⁺ binders. We included patients in an unblinded two-arm crossover trial comparing SPS 15 g before each meal on non-dialysis days with PAT 16.8 g once daily on non-dialysis days with randomized attribution order and a 2-week inter

SUBMITTER: Jaques DA 

PROVIDER: S-EPMC9494516 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature