Increased LDL-cholesterol level is associated with deterioration of renal function in males.

ABSTRACT:

Background

Relationships between levels of serum lipid fractions and the time course of renal function are discrepant in the literature. Here we examined this issue by analyses of healthy subjects in a cohort.

Methods

Of all subjects who received health examinations at Keijinkai Maruyama Clinic, Sapporo in 2006, subjects with hypertension, diabetes mellitus or chronic kidney disease (CKD) and those taking medication for dyslipidemia were excluded and a total of 5586 subjects (male/female: 3563/2023, mean age: 43 ± 8 years) were followed for 10 years.

Results

Linear mixed effect models showed that baseline low-density lipoprotein-cholesterol (LDL-C) level was negatively associated with estimated glomerular filtration rate (eGFR) during the 10-year follow-up period afte

SUBMITTER: Osanami A 

PROVIDER: S-EPMC9494533 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature