Cell-Based Biohybrid Sensor Device for Chemical Source Direction Estimation.

ABSTRACT: This paper describes a method to estimate the direction from which the signal molecule reaches the sensor by using living cells. In this context, biohybrid sensors that utilize a sophisticated sensing system of cells can potentially offer high levels of chemical-detection sensitivity and selectivity. However, biohybrid-sensor-based chemical-source-direction estimation has not received research attention because the cellular response to chemicals has not been examined in the context of directional information. In our approach, we fabricated a device that can limit the interface between the cell-laden hydrogel and the chemical solution of interest to enhance the time difference over which the chemical solution reaches the cells. Chemical detection by cells that express specific receptors is

SUBMITTER: Oda H 

PROVIDER: S-EPMC9494699 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature