Ventral pallidum GABA neurons bidirectionally control opioid relapse across rat behavioral models.

ABSTRACT: Opioid addiction is a chronic, relapsing disorder. Whether addicted individuals are forced to abstain or they decide themselves to quit using drugs, relapse rates are high-especially upon encountering contexts and stimuli associated with prior opioid use. Rodents similarly show context- and cue-induced reinstatement of drug seeking following abstinence, and intriguingly, the neural circuits underlying these relapse-like behaviors differ when abstinence is involuntarily imposed, responding is extinguished, or animals decide themselves to cease taking drug. Here, we employ two complementary rat behavioral models of relapse-like behavior for the highly reinforcing opioid drug remifentanil, and asked whether GABAergic neurons in the ventral pallidum (VP^GABA) control opioid seeking u

SUBMITTER: Farrell MR 

PROVIDER: S-EPMC9494709 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature