Redox-Controlled Chemical Protein Synthesis: Sundry Shades of Latency.

ABSTRACT: The last two decades have witnessed the rise in power of chemical protein synthesis to the point where it now constitutes an established corpus of synthetic methods efficiently complementing biological approaches. One factor explaining this spectacular evolution is the emergence of a new class of chemoselective reactions enabling the formation of native peptide bonds between two unprotected peptidic segments, also known as native ligation reactions. In recent years, their application has fueled the production of homogeneous batches of large and highly decorated protein targets with a control of their composition at the atomic level. In doing so, native ligation reactions have provided the means for successful applications in chemical biology, medicinal chemistry, materials science, and nan

SUBMITTER: Agouridas V 

PROVIDER: S-EPMC9494750 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature