CDH1 overexpression predicts bladder cancer from early stage and inversely correlates with immune infiltration.

ABSTRACT:

Background

Bladder cancer (BC) seriously endangers public health, but effective biomarkers for BC diagnosis, particularly in the early stage, are still lacking. Identification of reliable biomarkers associated with early-stage BC is of great importance to early treatment and an improved outcome.

Methods

Differentially expressed genes (DEGs) were identified using four publicly available early-stage BC gene-expression profiles. Protein-protein interaction (PPI) and survival analysis for hub genes was evaluated. The correlation between methylation of genes and prognosis was evaluated using the MethSurv database. Co-expressed genes were explored using Cancer Cell Line Encyclopedia database and the corresponding expression were assessed in vitro. The competing endogenous RNA netw

SUBMITTER: Fan T 

PROVIDER: S-EPMC9494810 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature