The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates.

ABSTRACT:

Background

Up to 80% of cases of prostate cancer present with multifocal independent tumour lesions leading to the concept of a field effect present in the normal prostate predisposing to cancer development. In the present study we applied Whole Genome DNA Sequencing (WGS) to a group of morphologically normal tissue (n = 51), including benign prostatic hyperplasia (BPH) and non-BPH samples, from men with and men without prostate cancer. We assess whether the observed genetic changes in morphologically normal tissue are linked to the development of cancer in the prostate.

Results

Single nucleotide variants (P = 7.0 × 10^-03, Wilcoxon rank sum test) and small insertions and deletions (indels, P = 8.7 × 10^-06) were significantly higher in morphologically no

SUBMITTER: Buhigas C 

PROVIDER: S-EPMC9494848 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature