Vitamin D₃ Metabolic Enzymes in Plateau Zokor (Myospalax baileyi) and Plateau Pika (Ochotona curzoniae): Expression and Response to Hypoxia.

ABSTRACT: Vitamin D₃ (D₃) is produced endogenously from 7-dehydrocholesterol by irradiation and is an important secosteroid for the absorption of calcium and phosphate. Lithocholic acid (LCA) increases intestinal paracellular calcium absorption in a vitamin D receptor-dependent manner in vitamin D-deficient rats. The plateau zokor (Myospalax baileyi), a strictly subterranean species, and plateau pika are endemic to the Qinghai-Tibet Plateau. To verify whether the zokors were deficient in D₃ and reveal the effects of hypoxia on D₃ metabolism in the zokors and pikas, we measured the levels of 25(OH)D₃, calcium, and LCA, and quantified the expression levels of D₃ metabolism-related genes. The results showed an undetectable serum l

SUBMITTER: Chen X 

PROVIDER: S-EPMC9495108 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature