Clinical Impact of a Pharmacist-Driven Prospective Audit with Intervention and Feedback on the Treatment of Patients with Bloodstream Infection.

ABSTRACT: Evidence for the utility of pharmacist-driven antimicrobial stewardship programs remains limited. This study aimed to evaluate the usefulness of our institutional pharmacist-driven prospective audit with intervention and feedback (PAF) on the treatment of patients with bloodstream infections (BSIs). The effect of pharmacist-driven PAF was estimated using an interrupted time series analysis with a quasi-experimental design. The proportion of de-escalation during BSI treatment increased by 44% after the implementation of pharmacist-driven PAF (95% CI: 30-58, p < 0.01). The number of days of therapy decreased by 16 per 100 patient days for carbapenem (95% CI: -28 to -3.5, p = 0.012) and by 15 per 100 patient days for tazobactam/piperacillin (95% CI: -26 to -4.9, p <

SUBMITTER: Okada N 

PROVIDER: S-EPMC9495130 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature