Systematic Review with Trial Sequential Analysis of Prophylactic Antibiotics for Acute Pancreatitis.

ABSTRACT:

Background/objectives

Prophylactic antibiotics (PAB) are being still widely used for treatment of acute pancreatitis (AP) despite trials showing no firm evidence of efficacy. We aimed to evaluate effects of PAB for AP in a meta-analysis and the need for further research by trial sequential analysis (TSA).

Methods

Medline, Scopus and Web of Science were searched for randomized clinical trials. Primary outcomes were all infections and mortality. Secondary outcomes comprised infected pancreatic necrosis (IPN), specific infections, organ failure, surgical interventions, and length of hospital stay.

Results

Twenty-one trials with 1383 pts were included. PAB were received by 703 pts, while 680 were controls. Mortality was similar with RR 0.85 (95% CI 0.66-1.10). Infections

SUBMITTER: Poropat G 

PROVIDER: S-EPMC9495153 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature