IL-2 and IL-15 drive intrathymic development of distinct periphery-seeding CD4⁺Foxp3⁺ regulatory T lymphocytes.

ABSTRACT: Development of Foxp3-expressing regulatory T-lymphocytes (Treg) in the thymus is controlled by signals delivered in T-cell precursors via the TCR, co-stimulatory receptors, and cytokine receptors. In absence of IL-2, IL-15 or their receptors, fewer Treg apparently develop in the thymus. However, it was recently shown that a substantial part of thymic Treg are cells that had recirculated from the periphery back to the thymus, troubling interpretation of these results. We therefore reassessed the involvement of IL-2 and IL-15 in the development of Treg, taking into account Treg-recirculation. At the age of three weeks, when in wt and IL-15-deficient (but not in IL-2-deficient) mice substantial amounts of recirculating Treg are present in the thymus, we found similarly reduced proporti

SUBMITTER: Apert C 

PROVIDER: S-EPMC9495261 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature