Mem3DG: Modeling membrane mechanochemical dynamics in 3D using discrete differential geometry.

ABSTRACT: Biomembranes adopt varying morphologies that are vital to cellular functions. Many studies use computational modeling to understand how various mechanochemical factors contribute to membrane shape transformations. Compared with approximation-based methods (e.g., finite element method [FEM]), the class of discrete mesh models offers greater flexibility to simulate complex physics and shapes in three dimensions; its formulation produces an efficient algorithm while maintaining coordinate-free geometric descriptions. However, ambiguities in geometric definitions in the discrete context have led to a lack of consensus on which discrete mesh model is theoretically and numerically optimal; a bijective relationship between the terms contributing to both the energy and forces from the discrete and

SUBMITTER: Zhu C 

PROVIDER: S-EPMC9495267 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature