The Catalase KatA Contributes to Microaerophilic H₂O₂ Priming to Acquire an Improved Oxidative Stress Resistance in Staphylococcus aureus.

ABSTRACT: Staphylococcus aureus has to cope with oxidative stress during infections. In this study, S. aureus was found to be resistant to 100 mM H₂O₂ during aerobic growth. While KatA was essential for this high aerobic H₂O₂ resistance, the peroxiredoxin AhpC contributed to detoxification of 0.4 mM H₂O₂ in the absence of KatA. In addition, the peroxiredoxins AhpC, Tpx and Bcp were found to be required for detoxification of cumene hydroperoxide (CHP). The high H₂O₂ tolerance of aerobic S. aureus cells was associated with priming by endogenous H₂O₂ levels, which was supported by an oxidative shift of the bacillithiol redox potential to -291 mV compared to -310 mV in micro

SUBMITTER: Linzner N 

PROVIDER: S-EPMC9495333 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature