The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance?

ABSTRACT: The SH2 containing protein tyrosine phosphatase 2(SHP2) plays essential roles in fundamental signaling pathways, conferring on it versatile physiological functions during development and in homeostasis maintenance, and leading to major pathological outcomes when dysregulated. Many studies have documented that SHP2 modulation disrupted glucose homeostasis, pointing out a relationship between its dysfunction and insulin resistance, and the therapeutic potential of its targeting. While studies from cellular or tissue-specific models concluded on both pros-and-cons effects of SHP2 on insulin resistance, recent data from integrated systems argued for an insulin resistance promoting role for SHP2, and therefore a therapeutic benefit of its inhibition. In this review, we will summarize the genera

SUBMITTER: Saint-Laurent C 

PROVIDER: S-EPMC9495760 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature