Alternative Routes of Administration for Therapeutic Antibodies-State of the Art.

ABSTRACT:

Background

For the past two decades, there has been a huge expansion in the development of therapeutic antibodies, with 6 to 10 novel entities approved each year. Around 70% of these Abs are delivered through IV injection, a mode of administration allowing rapid and systemic delivery of the drug. However, according to the evidence presented in the literature, beyond the reduction of invasiveness, a better efficacy can be achieved with local delivery. Consequently, efforts have been made toward the development of innovative methods of administration, and in the formulation and engineering of novel Abs to improve their therapeutic index.

Objective

This review presents an overview of the routes of administration used to deliver Abs, different from the IV route, whether approved

SUBMITTER: Pitiot A 

PROVIDER: S-EPMC9495858 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature