Epigenetic Suppression of the IL-7 Pathway in Progressive Glioblastoma.

ABSTRACT:

Background

Immune evasion in glioblastoma (GBM) shields cancer cells from cytotoxic immune response.

Methods

We investigated CpG methylation in promoters, genes, and pathways in 22 pairs of formalin-fixed paraffin-embedded sequential (FFPE) GBM using restricted resolution bisulfite sequencing (RRBS) and bioinformatic analyses.

Results

Gene ontology revealed hypermethylation in elements of the innate and adaptive immune system when recurrent GBM samples (GBM^rec) were compared to control (CG) and primary GBM samples (GBM^prim). Higher methylation levels of the IL-7 signaling pathway and response to IL-7 were found in GBM^rec suggesting a progressive blockade of the IL-7 driven T cell response in sequential GBM. Analyses of the Cancer Genom

SUBMITTER: Tompa M 

PROVIDER: S-EPMC9496096 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature