Alterations of the Composition and Neurometabolic Profile of Human Gut Microbiota in Major Depressive Disorder.

ABSTRACT: Major depressive disorder (MDD) is among the most prevalent mental disorders worldwide. Factors causing the pathogenesis of MDD include gut microbiota (GM), which interacts with the host through the gut-brain axis. In previous studies of GM in MDD patients, 16S rRNA sequencing was used, which provided information about composition but not about function. In our study, we analyzed whole metagenome sequencing data to assess changes in both the composition and functional profile of GM. We looked at the GM of 36 MDD patients, compared with that of 38 healthy volunteers. Comparative taxonomic analysis showed decreased abundances of Faecalibacterium prausnitzii, Roseburia hominis, and Roseburia intestinalis, and elevated abundances of Escherichia coli and Rutheniba

SUBMITTER: Kovtun AS 

PROVIDER: S-EPMC9496097 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature