Novel Fluorescence Probe toward Cu²⁺ Based on Fluorescein Derivatives and Its Bioimaging in Cells.

ABSTRACT: Copper is an important trace element that plays a crucial role in various physiological and biochemical processes in the body. The level of copper content is significantly related to many diseases, so it is very important to establish effective and sensitive methods for copper detection in vitro and vivo. Copper-selective probes have attracted considerable interest in environmental testing and life-process research, but fewer investigations have focused on the luminescence mechanism and bioimaging for Cu²⁺ detection. In the current study, a novel fluorescein-based A5 fluorescence probe is synthesized and characterized, and the bioimaging performance of the probe is also tested. We observed that the A5 displayed extraordinary selectivity and sensitivity properties to Cu²⁺

SUBMITTER: Leng X 

PROVIDER: S-EPMC9496130 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature