Investigational Treatments in Phase I and II Clinical Trials: A Systematic Review in Asthma.

ABSTRACT: Inhaled corticosteroids (ICS) remain the mainstay of asthma treatment, along with bronchodilators serving as control agents in combination with ICS or reliever therapy. Although current pharmacological treatments improve symptom control, health status, and the frequency and severity of exacerbations, they do not really change the natural course of asthma, including disease remission. Considering the highly heterogeneous nature of asthma, there is a strong need for innovative medications that selectively target components of the inflammatory cascade. The aim of this review was to systematically assess current investigational agents in Phase I and II randomised controlled trials (RCTs) over the last five years. Sixteen classes of novel therapeutic options were identified from 19 RCTs. Drugs

SUBMITTER: Calzetta L 

PROVIDER: S-EPMC9496184 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature