Causal effects of gut microbiota on diabetic retinopathy: A Mendelian randomization study.

ABSTRACT:

Background

Previous researches have implicated a vital association between gut microbiota (GM) and diabetic retinopathy (DR) based on the association of the "gut-retina" axis. But their causal relationship has not been elucidated.

Methods

Instrumental variables of 211 GM taxa were obtained from genome wide association study (GWAS), and Mendelian randomization study was carried out to estimate their effects on DR risk from FinnGen GWAS (14,584 DR cases and 202,082 controls). Inverse variance weighted (IVW) is the main method to analyze causality, and MR results are verified by several sensitive analyses.

Results

As for 211 GM taxa, IVW results confirmed that family-Christensenellaceae (P = 1.36×10^-2) and family-Peptococcaceae (P =

SUBMITTER: Liu K 

PROVIDER: S-EPMC9496187 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature