DNA Methylation in Regulatory T Cell Differentiation and Function: Challenges and Opportunities.

ABSTRACT: As a bona fide epigenetic marker, DNA methylation has been linked to the differentiation and function of regulatory T (Treg) cells, a subset of CD4 T cells that play an essential role in maintaining immune homeostasis and suppressing autoimmunity and antitumor immune response. DNA methylation undergoes dynamic regulation involving maintenance of preexisting patterns, passive and active demethylation, and de novo methylation. Scattered evidence suggests that these processes control different stages of Treg cell lifespan ranging from lineage induction to cell fate maintenance, suppression of effector T cells and innate immune cells, and transdifferentiation. Despite significant progress, it remains to be fully explored how differential DNA methylation regulates Treg cell fate and immu

SUBMITTER: Bai L 

PROVIDER: S-EPMC9496199 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature