Regenerative Potential of A Bovine ECM-Derived Hydrogel for Biomedical Applications.

ABSTRACT: Recent advancements in regenerative medicine have enhanced the development of biomaterials as multi-functional dressings, capable of accelerating wound healing and addressing the challenge of chronic wounds. Hydrogels obtained from decellularized tissues have a complex composition, comparable to the native extracellular environment, showing highly interesting characteristics for wound healing applications. In this study, a bovine pericardium decellularized extracellular matrix (dECM) hydrogel was characterized in terms of macromolecules content, and its immunomodulatory, angiogenic and wound healing potential has been evaluated. The polarization profile of human monocytes-derived macrophages seeded on dECM hydrogel was assessed by RT-qPCR. Angiogenic markers expression has been evaluated b

SUBMITTER: Di Francesco D 

PROVIDER: S-EPMC9496624 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature