A New Product of Bilirubin Degradation by H₂O₂ and Its Formation in Activated Neutrophils and in an Inflammatory Mouse Model.

ABSTRACT: Bilirubin (BR) is a tetrapyrrolic compound stemming from heme catabolism with diverse physiological functions. It can be oxidized by H₂O₂ to form several degradation products, some of which have been detected in vivo and may contribute to the pathogenesis of certain diseases. However, the oxidative degradation of BR is complex and the conditions that BR degradation occurs pathophysiologically remain obscure. Neutrophils are known to generate large amounts of reactive oxygen species, including H₂O₂, upon activation and they are mobilized to inflammatory sites; therefore, we hypothesized that activated neutrophils could cause BR degradation, which could occur at inflammatory sites. In the present study, we investigated BR degradation by H₂

SUBMITTER: Yu FF 

PROVIDER: S-EPMC9496627 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature