IgG⁺ Extracellular Vesicles Measure Therapeutic Response in Advanced Pancreatic Cancer.

ABSTRACT: (1) Background: Pancreatic ductal adenocarcinoma (PDAC) is expected to be the second-leading cause of cancer deaths by 2030. Imaging techniques are the standard for monitoring the therapy response in PDAC, but these techniques have considerable limits, including delayed disease progression detection and difficulty in distinguishing benign from malignant lesions. Extracellular vesicle (EV) liquid biopsy is an emerging diagnosis modality. Nonetheless, the majority of research for EV-based diagnosis relies on point analyses of EVs at specified times, while longitudinal EV population studies before and during therapeutic interventions remain largely unexplored. (2) Methods: We analyzed plasma EV protein composition at diagnosis and throughout PDAC therapy. (3) Results: We found that IgG is lin

SUBMITTER: Couto N 

PROVIDER: S-EPMC9496671 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature