Killer-Cell Immunoglobulin-like Receptor Diversity in an Admixed South American Population.

ABSTRACT: Natural Killer (NK) cells are innate immune cells that mediate antiviral and antitumor responses. NK cell activation and induction of effector functions are tightly regulated by the integration of activating and inhibitory receptors such as killer immunoglobulin-like receptors (KIR). KIR genes are characterized by a high degree of diversity due to presence or absence, gene copy number and allelic polymorphism. The aim of this study was to establish the distribution of KIR genes and genotypes, to infer the most common haplotypes in an admixed Colombian population and to compare these KIR gene frequencies with some Central and South American populations and worldwide. A total of 161 individuals from Medellin, Colombia were included in the study. Genomic DNA was used for

SUBMITTER: Castrillon M 

PROVIDER: S-EPMC9496851 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature