Targeting Mutant p53 for Cancer Treatment: Moving Closer to Clinical Use?

ABSTRACT: Mutant p53 is one of the most attractive targets for new anti-cancer drugs. Although traditionally regarded as difficult to drug, several new strategies have recently become available for targeting the mutant protein. One of the most promising of these involves the use of low molecular weight compounds that promote refolding and reactivation of mutant p53 to its wild-type form. Several such reactivating drugs are currently undergoing evaluation in clinical trials, including eprenetapopt (APR-246), COTI-2, arsenic trioxide and PC14586. Of these, the most clinically advanced for targeting mutant p53 is eprenetapopt which has completed phase I, II and III clinical trials, the latter in patients with mutant TP53 myelodysplastic syndrome. Although no data on clinical efficacy are current

SUBMITTER: Duffy MJ 

PROVIDER: S-EPMC9496879 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature