High-Dose Mycobacterium tuberculosis H37rv Infection in IL-17A- and IL-17A/F-Deficient Mice.

ABSTRACT: During experimental tuberculosis (TB), interleukin (IL)-17A appears to be involved in the formation of lung granulomas, possibly through the attraction of neutrophils to the sites of infection. However, the protective impact of cytokine appears to depend on the degree of its induction. Hence, robust production of IL-17A in mice infected with the hypervirulent isolate Mycobacterium tuberculosis (Mtb) HN878 mediates protection, while the cytokine is dispensable for protective immune responses against low-dose infection with the less virulent strain H37rv. Here, we show that after experimental infection with high doses of Mtb H37rv, IL-17A-deficient (^-/-) mice exhibited high susceptibility to the infection, which was mediated by the strong accumulation of neutrophils in the

SUBMITTER: Ritter K 

PROVIDER: S-EPMC9496946 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature