Androgen Receptor Splice Variants Contribute to the Upregulation of DNA Repair in Prostate Cancer.

ABSTRACT:

Background

Canonical androgen receptor (AR) signaling regulates a network of DNA repair genes in prostate cancer (PCA). Experimental and clinical evidence indicates that androgen deprivation not only suppresses DNA repair activity but is often synthetically lethal in combination with PARP inhibition. The present study aimed to elucidate the impact of AR splice variants (AR-Vs), occurring in advanced or late-stage PCA, on DNA repair machinery.

Methods

Two hundred and seventy-three tissue samples were analyzed, including primary hormone-naïve PCA, primary metastases, hormone-sensitive PCA on androgen deprivation therapy (ADT) and castration refractory PCA (CRPC group). The transcript levels of the target genes were profiled using the nCounter platform. Experimental support for

SUBMITTER: Tolkach Y 

PROVIDER: S-EPMC9496991 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature