Boosting the Immune Response-Combining Local and Immune Therapy for Prostate Cancer Treatment.

ABSTRACT: Due to its slow progression and susceptibility to radical forms of treatment, low-grade PC is associated with high overall survival (OS). With the clinical progression of PC, the therapy is becoming more complex. The immunosuppressive tumor microenvironment (TME) makes PC a difficult target for most immunotherapeutics. Its general immune resistance is established by e.g., immune evasion through Treg cells, synthesis of immunosuppressive mediators, and the defective expression of surface neoantigens. The success of sipuleucel-T in clinical trials initiated several other clinical studies that specifically target the immune escape of tumors and eliminate the immunosuppressive properties of the TME. In the settings of PC treatment, this can be commonly achieved with radiation therapy (RT). In

SUBMITTER: Karwacki J 

PROVIDER: S-EPMC9496996 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature