MicroRNA-4516 in Urinary Exosomes as a Biomarker of Premature Ovarian Insufficiency.

ABSTRACT: Premature ovarian insufficiency (POI) is a typical disorder of amenorrhea that lasts for a minimum of four months in women < 40 years old and is typically characterized by reduced estrogen levels and elevated serum concentrations of follicle-stimulating hormone. We collected urine samples from two participant cohorts from Gil Hospital of Gachon University (Incheon, Korea): a sequencing cohort of 19 participants (seven patients with POI (POI patients without Turner syndrome), seven patients with Turner syndrome (POI patients with Turner syndrome), and five control individuals (age-matched controls with confirmed ovarian sufficiency)) and a validation cohort of 46 participants (15 patients with POI, 11 patients with Turner syndrome, and 20 control individuals). Among differentially expressed

SUBMITTER: Umair Z 

PROVIDER: S-EPMC9497098 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature