Systematic Review of the Role of Alpha-Protein Kinase 1 in Cancer and Cancer-Related Inflammatory Diseases.

ABSTRACT:

Background

Deregulation of conventional protein kinases is associated with the growth and development of cancer cells. Alpha-kinase 1 (ALPK1) belongs to a newly discovered family of serine/threonine protein kinases with no sequence homology to conventional protein kinases, and its function in cancer is poorly understood.

Methods

In this systematic review, we searched for and analyzed studies linking ALPK1 to cancer development and progression.

Results

Based on the current evidence obtained using human, animal, cellular, and tissue models, ALPK1 is located upstream and triggers cancer cell development and metastasis by regulating the inflammatory response through phosphorylation. Its mRNA and protein levels were found to correlate with advanced tumor size and lymph nod

SUBMITTER: Ko AM 

PROVIDER: S-EPMC9497133 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature