Identification of a Biomarker Combination for Survival Stratification in pStage II/III Gastric Cancer after Curative Resection.

ABSTRACT:

Background

We sought to identify an optimal combination of survival risk stratification markers in patients with pathological (p) stage II/III gastric cancer (GC) after curative resection.

Methods

We measured the expression levels of 127 genes in pStage II/III GC tissues of two patient cohorts by quantitative polymerase chain reaction (qPCR) and the expression of 1756 proteins between two prognosis (good and poor) groups by proteomic analysis to identify candidate survival stratification markers. Further, immunohistochemistry (IHC) using tumor microarrays (TMAs) in another cohort of patients was performed to identify an optimal biomarker combination for survival stratification in GC patients.

Results

secreted protein acidic and rich in cysteine (SPARC), erb-b2 recepto

SUBMITTER: Hashimoto I 

PROVIDER: S-EPMC9497152 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature