Golgi Protein 73 (GP73) Serum Levels Predict Outcome after Resection of Biliary Tract Cancer.

ABSTRACT:

Background

Tumor resection represents the only potentially curative therapy for patients with biliary tract cancer. Nevertheless, disease recurrence is observed in about 50% of patients, leading to a 5-years survival rate of less than 50%. The Golgi protein 73 (GP73), a type II Golgi transmembrane protein, exerts important functions of intracellular protein processing and transportation. Circulating GP73 has recently been suggested as a prognostic marker following resection of hepatocellular carcinoma (HCC) but its role in the context of BTC has remained unknown. In this study, we evaluate a potential role of circulating GP73 as a novel biomarker in patients with resectable BTC.

Methods

GP73 serum levels were measured by immunoassay in n = 97 BTC and n = 40 HCC patients as w

SUBMITTER: Loosen SH 

PROVIDER: S-EPMC9497317 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature