Identification of molecular patterns and diagnostic biomarkers in juvenile idiopathic arthritis based on the gene expression of m⁶A regulators.

ABSTRACT: The role of N ⁶-methyladenosine modification in immunity is increasingly being appreciated. However, the landscape of m⁶A regulators in juvenile idiopathic arthritis (JIA) is poorly understood. Thus, this study explored the impact of m⁶A modification and related lncRNAs in JIA immune microenvironment. Fourteen m⁶A regulators and eight lncRNAs were identified as potential diagnostic biomarkers for JIA. Two diagnostic models for JIA were also constructed. The putative molecular regulatory mechanism of FTO-mediated m⁶A modification in JIA was hypothesized. Three distinct m⁶A patterns mediated by 26 m⁶A regulators and three diverse lncRNA clusters mediated by 405 lncRNAs were thoroughly investigated. The

SUBMITTER: Zhang S 

PROVIDER: S-EPMC9497457 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature