Circulating Angiogenic Markers in Gastroenteropancreatic Neuroendocrine Neoplasms: A Systematic Review.

ABSTRACT:

Background

Neuroendocrine neoplasms are a heterogeneous group of tumors that raise challenges in terms of diagnosis, treatment and monitoring. Despite continuous efforts, no biomarker has showed satisfying accuracy in predicting outcome or response to treatment.

Methods

We conducted a systematic review to determine relevant circulating biomarkers for angiogenesis in neuroendocrine tumors. We searched three databases (Pubmed, Embase, Web of Science) using the keywords "neuroendocrine" and "biomarkers", plus specific biomarkers were searched by full and abbreviated name. From a total of 2448 publications, 11 articles met the eligibility criteria.

Results

VEGF is the most potent and the most studied angiogenic molecule, but results were highly controversial. Placental gr

SUBMITTER: Sandra I 

PROVIDER: S-EPMC9497497 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature