Expression and Prognostic Value of Chromobox Family Proteins in Esophageal Cancer.

ABSTRACT:

Background

Esophageal cancer (EC) is one of the most common human malignant tumors worldwide. Chromobox (CBX) family proteins are significant components of epigenetic regulatory complexes. It is reported that CBXs play critical roles in the oncogenesis and development of various tumors. Nonetheless, their functions and specific roles in EC remain vague and obscure.

Methods and materials

We used multiple bioinformatics tools, including Oncomine, Gene Expression Profiling Interactive Analysis 2 (GEPIA2), UALCAN, Kaplan-Meier plotter, cBioPortal, Metascape, TIMER2 and TISIDB, to investigate the expression profile, gene alterations and prognostic roles of CBX family proteins, as well as their association with clinicopathologic parameters, immune cells and immune regulators. In a

SUBMITTER: Liu J 

PROVIDER: S-EPMC9498422 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature