MintRULS: Prediction of miRNA-mRNA Target Site Interactions Using Regularized Least Square Method.

ABSTRACT: Identification of miRNA-mRNA interactions is critical to understand the new paradigms in gene regulation. Existing methods show suboptimal performance owing to inappropriate feature selection and limited integration of intuitive biological features of both miRNAs and mRNAs. The present regularized least square-based method, mintRULS, employs features of miRNAs and their target sites using pairwise similarity metrics based on free energy, sequence and repeat identities, and target site accessibility to predict miRNA-target site interactions. We hypothesized that miRNAs sharing similar structural and functional features are more likely to target the same mRNA, and conversely, mRNAs with similar features can be targeted by the same miRNA. Our prediction model achieved an impressive AUC of 0.9

SUBMITTER: Shakyawar S 

PROVIDER: S-EPMC9498445 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature