Design and Optimization of In Situ Gelling Mucoadhesive Eye Drops Containing Dexamethasone.

ABSTRACT: Poor bioavailability of eye drops is a well-known issue, which can be improved by increasing the residence time on the eye surface and the penetration of the active pharmaceutical ingredient (API). This study aims to formulate in situ gelling mucoadhesive ophthalmic preparations. To increase the residence time, the formulations were based on a thermosensitive polymer (Poloxamer 407 (P407)) and were combined with two types of mucoadhesive polymers. Dexamethasone (DXM) was solubilized by complexation with cyclodextrins (CD). The effect of the composition on the gel structure, mucoadhesion, dissolution, and permeability was investigated with 3³ full factorial design. These parameters of the gels were measured by rheological studies, tensile test, dialysis membrane diffusion, and in

SUBMITTER: Szalai B 

PROVIDER: S-EPMC9498616 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature